Wednesday, May 13, 2009

The "Gay Gene" Part I

I had an interesting conversation with Bob (and briefly with AJ) the other night. Currently biomedical science does not support the hypothesis of a single "gay gene." But suppose a single gene were discovered that overwhelmingly determines sexuality, what would the ramifications be? Would it be a boon or a blow to the LGBTQ community?

In this installment, I will make the argument that the discovery of a single gay gene would be one of the greatest blow to the LGBTQ community, judging by the direction medical genetics is headed. In Part II, I'll briefly summarize the current literature on the genetics of sexuality. And in Part III, I'll posit a possible genetic model of sexuality. Hang on and read slowly, otherwise things might just fly right past over your heads.

First, a review of Mendelian genetics. We have genes that control particular traits. Each person has 2 versions of any given gene (called alleles), one inherited from each parent. Alleles may be dominant or recessive, with the dominant allele of a gene "masking" the recessive allele. In regards to sexuality, let's say heterosexuality is "dominant" and homosexuality is "recessive." If a person has one "hetero" allele and one "homo" allele, that person will be heterosexual. The only way that person can be homosexual is if he/she inherits two "homo" alleles.

Now let's expand upon this model (and ignore bisexuals for the moment - there is a way to make bisexuality "fit" in this model, but the genetics of that is beyond the scope of this post). Let's say a single gene is discovered that overwhelmingly affects sexuality. With this discovery, sexuality is overwhelmingly determined to be "nature" and not "nurture" (a faulty dichotomy to begin with, but we'll ignore that). We can rejoice in knowing that individuals are born straight or gay and have little/no choice in the matter.

Initially this may be cause for celebration, but it won't be for long. If the gene has been discovered then it can be detected. If it's detectable, then it can be found and individuals screened for the "gay allele" of this gene. There is a technology available now, today, called PGD (pre-implantation genetic diagnosis) that allows scientists to screen embryos for particular alleles of certain genes. Through PGD, embryos can be screened so only the desirable embryos are implanted into the womb. If the "gay allele" is undesirable, embryos with that allele can be screened out so no homosexual individuals are born.

Alternatively, genetics is advancing at such a pace that gene therapy may become feasible in the near-ish future. If, through this discovery, homosexuality is viewed as a "diseases state," then research money will flow into the development of a "cure" to "fix" homosexuals and make them straight. Imagine taking a pill or getting a shot and changing your sexual orientation. If this outcome becomes a possibility, then the individual's consent might not even be necessary for these "cures" to be dispensed. If given to a minor before the age of medical consent, parents could force their "gay-to-be" children to take the pill or shot and "make" them straight.

Think for a moment: if you knew that your offspring could be gay, would you want him/her to go through the teasing, ridicule, and whatever emotional baggage comes with being gay because of societal and cultural norms? For most parents the answer is probably no - they would prevent such a future for their child if they could. And if a child is already born, well, a "cure" is on the way. Before you decry the above as science fiction, or say that even if it's a reality it will never happen, it's already too late. Similar cases have already begun. The prime example is deafness.

Deaf parents (the capital "D" is important) often wish to have deaf children so that their children may grow up as a part of the Deaf community. The Deaf community does not view deafness as a disability or a handicap; deafness is merely a normal variation within humans, and deaf individuals have their own culture. Deaf parents might utilize PGD to screen for embryos that may become deaf children, and thus screen out the "normal" children. In contrast, hearing parents view deafness as a disability/handicap. They will go to lengths to ensure their children are as "normal" as possible. This may include PGD, but more often than not they utilize cochlear implants to help their children hear. Deaf parents tend to find cochlear implants an abomination - a means to quash Deaf culture and suppress a minority.

How many parallels do you see between the LGBTQ community and the Deaf community in these regards? Because of this I find the prospect of discovering a single "gay gene" to be a very scary one. It only requires a tiny push from well-meaning genetics to tip into the dark history of eugenics. And I haven't even touched on the issue of health insurance and life insurance yet. Thank God that human behavior is too complex to be controlled by "merely" a single gene.

---TANGENT---
I've begun talking to a new blogger, AJ (yes, a "second" AJ), and have just caught up on his blog: coming out (on the net). Great kid, do go over to his blog, say hi, and make him feel welcomed.

Hey AJ, I apologize that I stuck this blurb at the end of a rather intense post. I just wanted to give you a shout out before I forget.
---END TANGENT---

Sunday, May 10, 2009

Time Limit's Almost Up

Okay, time limit's almost up.

Every time I come home, I seem to want to be home for a shorter and shorter duration. I mean, seriously, I've only been home since Tuesday and already I want to leave! Parental nagging gets more and more annoying. I would fire off my mouth like my youngest brother, but that would not lead to (good) results. No, best to let the wave hit and pass than fight the wave and be consumed by an even greater fury.

I must say, I am amused that my parents are nagging me about going to China for the month of June. As if I didn't know the proper etiquette and culture (which I DO know most of the "rules"). Seriously, I think perhaps my parents have issues letting go and recognizing that my brothers and I have/are grown up.

And my other brother is taking the MCAT and applying to med schools this summer. And so that round of all too familiar nagging begins - this time towards him and not me. It's interesting watching the exchange, the whole "good cop bad cop" routine. "You should do this!" says dad. "Well, we're not actually asking for that. Do only half that," says mom (and even half whatever is still an undertaking). And the bouncing of dialogue between one another, ganging up - I HATE that. Ugh.

Then they drag me in. "Why don't you help your brother? You've already gone through the process, you know what to do and what not to do. Tell him!" Why, I would love to tell him. But first he must ask me what he wants to know and also be receptive to hearing what I have to say. I also want him to try to wade through things a bit on his own so I'm not guiding his hand through the damned med school application process. It didn't exactly go peachy perfect for me when I went through that process . . .

Okay, enough ranting. Anyway, moral of all this ranting is: home is good for a short duration. But the time limit's almost up and soon I might go insane. Just a couple more weeks until China . . . speaking of which, I should REALLY get to planning what I'm going to do once I land (if for no other reason than to appease my parents and get them off my backs - but they have a good point, they usually do, it's just executed poorly).

---TANGENT---
A pretty new and still shiny blog! Check out Jeremy at Falling Through the Void. Great guy, great to chat with, even if he's a little shy on asking questions.
---END TANGENT---

Wednesday, May 6, 2009

Summer Starts Now

Summer starts now.

I'm home now for the summer. Not working this summer; I usually work in a lab for most of the summer, but not this year. I'm taking this summer right before med school easy. I still need to find an apartment and roommate for this next academic year in med school . . . but I think I'll wait until the orientation stuff is available online. Supposedly they'll have a means to contact other incoming med students as well as housing info.

My parents bought me tickets to China!! I'll be leaving May 31st and coming back June 27th. The tickets were "free" due to my dad's frequent flyer miles (I only have about half as many miles as he does, so I could've bought a "free" ticket one-way to China). I'll most likely be staying with a great-uncle and his side of the family while I'm there in Beijing. I don't know them at all, so this'll be interesting. Additionally, JW-M and RZ-F will both be in Beijing during my time there.

I plan to spend a few days with JW-M and a week or so with RZ-F. That leaves about 2 weeks for me to bond (or whatnot) with my family there. I'm so excited! And yet, apprehensive. Same reasons as last time I went - what if my Chinese isn't good enough? This time I'll have to really step up my game, as last time I went with a group of people from school and we had each other's backs. Plus, my Chinese last time was mostly limited to "translation duty," which is easier than maintaining a full conversation in Chinese at length. Also, this time I'll have to find and coordinate correspondences with my roommate-to-be in the fall at med school (so having the internet is a necessity - but this shouldn't be difficult to obtain).

Anyway, other than that, I've no solid idea of what I'll be doing in China. Any suggestions/ideas? I am, however, somewhat bound by who I'm with at any moment.

In other news, my last final grade has been released to my transcript. Stupid biostatistics course - I took your final 2 weeks ago and you JUST post the grades?! Sigh. Whatever, I got an A! This means I got straight A's this last semester in grad school. W00t! Totally 8.000'd that GPA (I think it's out of 9.000 . . . not sure). Pwn. :D

Alas, I somehow managed to gain 15 lbs in the last 3 weeks. Fuck. Time to start running, and eating not. Fail. :(

Saturday, May 2, 2009

The Things You Might Miss

We move ever quicker through life; the older we get, the quicker time seems to flow. If we were to slow down, would we know what to do with ourselves? What have you missed and passed by through life? Did you even notice?

The things you might miss, what will you see when you look:
Across the street?

Up?

To the Left?

To the Right?

Around the corner?

Down?

On your way to work?

In a corner?

On a fire hydrant?

Upon leaving the library?

After getting a quick drink and bite?

Randomly?

Yes, I'm glad I slowed down enough to see the hidden things before my eyes. I will miss this city. Chances are the next time I walk its streets, these scenes will be erased or replaced by others. All the more reason to value these snapshots in time.

Thursday, April 30, 2009

Mask of Teaching

At 6pm on Wednesday, April 29th, I completed my last duty as a GSI (graduate student instructor, for those who don't remember what that stands for): proctoring the Intro Genetics final.

One of my students (upon turning in her final exam) said to me, "You're literally the BEST GSI I've ever had. I'm not even kidding, seriously."

Later another one of my students (upon turning her final exam) said to me, "I just wanted to let you know that you are probably THE best science GSI I've ever had. One of my friends actually transferred into your section because his GSI sucked and I told him that you were amazing."

At one point, the professor came into the lecture hall where we were proctoring and whispered to me, "Several students in my office hours tell me that you do a great job explaining things to them. Good job, I thought I should tell you."

Much later, a friend (whose friend is in one of my discussion sections) told me, "So my friend K says you're her favorite GSI."

Clearly I must be doing something right, right? I mean, I somehow achieved the highest section attendance (almost everyone came to my later sections) out of all the GSIs, and discussion sections were completely voluntary so no one had to come. Funny story about that actually: on the day of my last discussion, one of my students (a male nurse who's older than me) brought his two little kids - around age 3 to 5 - to my discussion section. Somehow he felt that my discussion sections were necessary enough to attend, even though he could've easily skipped to take care of his kids? (Btw, his kids were adorable, and I just so happened to bring cookies that day, and they loved them.)

The Mask of Teaching, I LOVE wearing it. It brightens my day (usually) when I have to go in to teach my discussion sections. And it feels pretty damn good to receive such high praise and comments about the way I teach. I don't know what it is I do exactly, I just sort of teach on-the-fly with a very bare-boned lesson plan in my head. I do what I feel like would most benefit them in the 1 hour (well, 50 minutes) we have together. I have, however, identified a few things I think have helped a lot:

1. Make it relevant.
Students tend to not like the theoretical stuff. They need a way to take the concepts learned and integrate them into something they can relate to on a personal level. I often used the example of cancer genetics, because it fits so well with many topics. I also tried to link up some concepts to things like cardiovascular disease, family history, etc.

2. Organization.
It definitely helps to know what you're doing, what order you're doing it in, and how long you expect it to take. Even better if you've internalized that organization so you don't have to always have it in front of you.

3. Reflecting questions.
As I work out a problem on the board or present a concept, I constantly ask my students about the next "step." What happens now? What do you think I should do? Why do you think this is? How do you think this works? Etcetra. They may not always answer (and in one of my classes, they rarely do), but they are thinking and considering. This is much more effective in office hours where they have "nowhere to run." I force the students to try to solve the problem on their own, with me basically giving them sign posts and clarifications - only give directions if they're lost.

4. Visual learners.
I always draw up a diagram on the board and describe what I draw as I draw. Genetics is not a very tangible subject, so you have to somehow make things visual so they can more easily and readily comprehend it. Also, you have to actually draw it out, it does no good to just flash a picture or a diagram up. You need to walk through how the diagram's constructed, what makes it tick, so to speak.

5. Understanding their needs.
I think one of my greatest assets is that I understand where many of them are coming from. It wasn't so long ago that I was "in their shoes." I understand what many want out of the class (that is, nothing to do with it) and I hoped to make them actually interested in genetics so that things stick in their heads. So I put myself in their shoes, "If I were taking this course again, what would I want to learn? What would make it interesting and relevant? What do I want to take out of it?" With that in mind, I try to meet them at that level. The professor actually remarked (with a hint of sarcasm), "No wonder why they liked you. You're a pre-med GSI for pre-meds."

Anyway, I seriously LOVE teaching. I'm a little sad that it's over now. :( I taught a mini-course with JW-M a year ago on HIV/AIDS to 10 or so freshman undergrads. We discussed the social, biological, cultural, and political aspects of this disease (well, I did biological and cultural; JW-M did social and political). And now Intro Genetics. It's rather fulfilling, I find. You see that glimmer in their eyes, and you know you've reached someone, you've piqued someone's interest. And perhaps that someone will take that interest and do something great with it.

Teaching >>> research, hands down. Seriously, it's kind of hard to describe how much I've enjoyed teaching. While it was my job, it certainly didn't feel like one.

Wednesday, April 29, 2009

Farewell Feasts

Now that exams are over, my friends and I are well into commencing what I'd like to call the "farewell feasts." Basically, we spend the last remaining week or so we have together eating out at places that we all like, or eating at places we've never tried before (at least, not together as a group). Yes, we gorge ourselves and our pocketbooks suffer, but hey, it only happens once a year.

It started last week, when AG-F and her genetic counseling (GC) classmates went to go eat at this Japanese steakhouse. SR-F and I were also invited. In fact, AG-F's classmates have made me an "honorary genetic counselor." I'm pretty honored. ^_^ Anyway, half of the GC students brought their boyfriends/fiances (all the GC students are female) and that was cute. The food was pretty good at the steakhouse and we sat at the grill, where a chef cooked our food right in front of us. He did some fancy knifework, though he didn't nail every single technique (at one point, I thought the giant fork thing would fly out of his hand and impale my head against the chair).

Suffice to say, I've eaten WAY too much since last Friday. My stomach hurts after almost every meal that I eat with friends. As an additional consequence, I've gained like 5-7 lbs in the last 2-3 weeks. >.< And my free membership to the university gyms (that all students get) expires in 2 days because I'm no longer taking classes. Sigh, I need to find some good non-weights workouts. Anyone have any suggestions? I also need to really step up my cardio - I feel so unhealthy and weak right now.

Furthermore, I still need to pack to go home. Haven't started yet . . . I would pack, but I'm still working in my lab until Friday. And I don't have that much time at night because that's the time I'm spending out with friends. o_O

---TANGENT---
Bob M (cvn70) has started a blog, Riding the Wave.

Go over and say hi!! :D
---END TANGENT---

Friday, April 24, 2009

And Now, Exhaustion Sets In

Today was my last final exam - cancer epidemiology. Last night, in the span of about 5 hours, I had to learn about 11 cancers: hematopoietic (leukemia, lymphoma), bladder, liver, breast, endometrial, testicular, prostate, lung, colorectal, esophageal, and pancreatic.

Some random factoids:

1. Pancreatic, lung, and liver are perhaps the worst to get (of the ones in the list above). Such low survival rates. :(

2. Being Asian is protective against like all cancer except esophageal (potentially genetic, related to the reason why many Asians turn red when they drink) and liver (and really, for liver that's only because Southeast Asia has a high prevalence of Hepatitis B and C - gotta get them vaccines!).

3. Testicular cancer is really really weird. o_O Seriously, freaky.

And now, exhaustion sets in. Also, I'm more or less done with grad school here. Off to med school in late July/early August!! Still not sure if I'm going to complete my MPH, eventually.

---TANGENT---
I'd like to welcome back Zee at Where I Stand.

At the same time, I'd like to say a fond farewell to Matt at Brass Matt. I, for one, will miss reading your blog. :(

Lastly, does anyone know what happened to Fiction Writer's blog at Writing Fiction? It's gone now . . . not even a goodbye. :(
---END TANGENT---